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1.0 Tuesday 14th June 1997



Neurobiol Aging 18 (1): 13-19 (Jan 1997)

Recognition memory span in rhesus monkeys of advanced age.

Moss MB, Killiany RJ, Lai ZC, Rosene DL, Herndon JG

Department of Anatomy and Neurobiology, Boston University School of Medicine,MA 02118, USA.

Assessment of recognition memory was performed on eight rhesus monkeys of advanced age (25 to 27 years of age) using the delayed recognition span test (DRST). Their performance was compared to that of five young adult animals (5 to 7 years of age) on two stimulus conditions of the DRST: spatial position and color. Both trial unique and repeating series were used for each of the two conditions. As a group, aged monkeys were impaired on both the spatial and color conditions of the DRST, achieving about two-thirds of the span of the young adult group in each condition. Error analyses revealed that monkeys in the aged group also produced more perseverative responses (i.e., displacing the previously correct disk) than did young adults. Together the findings suggest that monkeys of advanced age are impaired on tasks with memory loading demand characteristics.

PMID: 8983028, MUID: 97137691



The delayed recognition span test was conducted on the advanced aged rhesus monkeys (25-27years of age) and young adult animals (5-7years of age). The two conditions tested (spatial position and color) revealed that the advanced aged rhesus monkeys did not perform as well as the young adult animals.


Brain Res Dev Brain Res 99 (2): 201-207 (Apr 18 1997)

Selective formation of silent synapses on immature postsynaptic cells in cocultures of chick neurons of different ages

Kiyosue K, Kasai M, Taguchi T

Department of Organic Materials, Osaka National Research Institute, Midorigaoka, Ikeda, Japan.

Glutamatergic synapses usually contain two types of ionotropic glutamate receptor, N-methyl-D-aspartate receptors (NMDARs) and non-NMDA receptors (non-NMDARs), and the ratio of these receptors is thought to be critical for synaptic plasticity. To determine whether or not the ratio of these receptors at synaptic sites is controlled by the developmental stage of postsynaptic neurons, we applied a dual whole-cell recording technique to a culture of dissociated chick cerebral neurons of different ages. We found that formation of synapses that contained both types of receptor required maturation of postsynaptic neurons. Moreover, during the early development of postsynaptic neurons, NMDARs were selectively present at synaptic sites prior to the presence of non-NMDARs, even though both types of receptor were expressed in functional form in the neuronal membranes.

PMID: 9125473, MUID: 97270390


Neurobiol Aging 17 (3): 325-330 (May 1996)

Premature aging in Werner's syndrome spares the central nervous system.

Postiglione A, Soricelli A, Covelli EM, Iazzetta N, Ruocco A, Milan G, Santoro L, Alfano B, Brunetti A

Department of Clinical and Experimental Medicine, University of Naples Federico II, Italy.

Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.

PMID: 8725892, MUID: 96338777


Neurobiol Aging 16 (1): 11-18 (Jan 1995)

No vasopressin cell loss in the human hypothalamus in aging and Alzheimer's disease.

Van der Woude PF, Goudsmit E, Wierda M, Purba JS, Hofman MA, Bogte H, Swaab DF

Graduate School of Neurosciences, Amsterdam, Netherlands Institute for Brain Research.

The total number of immunocytochemically identified vasopressin (AVP) cells was determined morphometrically in the paraventricular (PVN) and dorsolateral part of the supraoptic nucleus (dl-SON) of the human hypothalamus in 30 subjects ranging in age from 15 to 97 years, including 10 Alzheimer's disease (AD) patients. The aim of the present study was to test the hypothesis that the increased activity of AVP neurons reported earlier is accompanied by an absence of cell loss in these nuclei in senescence and AD. The results show that numbers of immunoreactive AVP cells in the PVN and dl-SON do not decline during aging or in AD. During aging, the number of neurons expressing AVP even increased in the PVN of control subjects. The nuclear diameter of the AVP cells in the PVN and dl-SON showed an increase in old AD patients. It is concluded that no cell loss occurs in the AVP cell population in the PVN and dl-SON during aging and in AD, and that AVP expression increases in the PVN during normal aging, but not in AD.

Substances: Argipressin

PMID: 7723930, MUID: 95240824


Neurobiol Aging 12 (5): 511-516 (Sep 1991)

Oxytocin cell number in the human paraventricular nucleus remains constant with aging and in Alzheimer's disease.

Wierda M, Goudsmit E, Van der Woude PF, Purba JS, Hofman MA, Bogte H, Swaab DF

Netherlands Institute for Brain Research, Amsterdam.

Total cell numbers in the paraventricular nucleus (PVN) were previously shown to remain unaltered with aging and in AD. The aim of the present study was to determine the aging pattern of the oxytocin (OXT) cell population in the PVN. For this purpose, the number of immunocytochemically identified oxytocin cells was determined in the PVN of the human hypothalamus in 20 control subjects ranging in age from 15 to 90 years and in 10 Alzheimer's disease (AD) patients aged 46 to 97 years. The results show that the number of OXT cells in the PVN is similar in males and females and remains unaltered in senescence and AD. It is concluded that the remarkable stability of the PVN in these conditions also applies for the subpopulation of OXT cells in this nucleus and that reports in the literature on diminished OXT secretion in AD do not seem to be based on a decrease in the number of OXT expressing neurons from the PVN.

Substances: Oxytocin

PMID: 1770986, MUID: 92123406



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