Geriatrics and Gerontology,
Cornell University Medical College,
For nearly 20 years the division of geriatrics and gerontology at Cornell University Medical College has had a research program primarily centered on the immunobiology of aging. The studies are performed in man and mouse with support largely of the national institute on aging. Clinical studies in man focus on the the effect of age on the response to influenza vaccine and the development of monoclonal lymphoid populations. Basic studies in humans and mice are the effect of age on the regulation of the development of lymphocyte and their repertoires. Age-associated shifts in repertoire are exemplified by the decreasing antibody response to most foreign antigens with age and the increase in antibody response to most auto-antigens. Similarly there is a shift in the pattern of cytokine secretion from Th1 to Th2 with age.
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