EUCAMBIS project

University of Tuebingen

Professor Graham Pawelec

Name: Professor Graham Pawelec
EUCAMBIS project
University of Tuebingen
Tuebingen
GERMANY.
E-Mail ----> graham.pawelec@med.uni-tuebingen.de
.

Topics:

My own lab is focussed on (in human only):

In vitro T cell culture as a model for immunosenescence

T cell differentiation

T cell immunobiology, particularly signal requirements for activation, anergy induction or apoptosis

Tumor immunology, particularly in leukemia and bone marrow transplantation

Histocompatibility immunogenetics

Cloning of potentially senescence-associated or growth arrest-mediating genes in T cells

Recent Publications:

1. Pawelec G: MHC-unrestricted immune surveillance of leukemia. Cancer Biotherapy 9:265-288, 1994

2. Pawelec G, Kalbacher H, Pohla H, Boshell M, Max H, Friccius H, Adibzadeh M, Hambrecht A, Sansom D: Requirements for stimulation or anergy induction in alloreactive human T cell clones. Cell Immunol 158: 241-252, 1994

3. Adibzadeh M, Buehring HJ, Daikeler T, Seigels-Huebenthal P, Owsianowski M, Schenk A, Rehbein A, Schaudt K, Schlotz E, Pohla H, Pawelec G: Extrathymic development and function of human T-lymphocytes from bone marow cells in vitro. Cell Immunol 154: 25-42, 1994

4. Pawelec G: Immune surveillance of leukemia: rationale for immunotherapy? Hematol Rev 8:123-147, 1994

5. Pawelec G: Suppressor cells in transplantation immunology: do recent advances in T cell immunobiology and cytokine networking contribute to the solution of an old conundrum? Transplant Immunol 1:172-181, 1993

6. Bruserud O, Ehninger G, Hamann W, Pawelec G: Secretion of IL 2, IL 3, IL 4, IL 6 and GM-CSF by CD4+ and CD8+ TCRalpha/beta + T cell clones derived early after allogeneic bone marrow transplantation. Scand J Immunol 38:65-74, 1993

7. Pohla H, Adibzadeh M, Buehring HJ, Siegels-Huebenthal P, Daikeler T, Owsianowski M, Schenk A, Rehbein A, Schlotz E, Schaudt K, Pawelec G: Developmental Immunol 3:197-210, 1993

8. Pawelec G: Cloning and propagation of human T lymphocytes. In: Tumor Immunobiology: A practical approach, eds G. Gallagher, RC Rees, CW Reynolds, IRL Pres, Oxford, pp. 131-141, 1993.

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