University of California, Berkeley
Berkeley,
California,
U.S.A.
Dr. Paola S. Timiras is a Professor in the Department of Molecular and Cell Biology at the University of California at Berkeley. Before joining the University of California in 1956, she was a faculty member of the University of Montreal (1950-1953) and the University of Utah (1953-1955). She chaired the Department of Physiology-Anatomy at the UCB from 1978 to 1984. Dr. Timiras's research in the fields of neuroendocrinology of development and aging has resulted in the publication of more than 350 papers and several books. Dr. Timiras was one of the founders and president (1978-1981) of the International Society of Developmental Neuroscience.
Selected Publications:
Medline. At the National Institutes of Health.
-
Effect of growth factors on the in vitro growth and differentiation of early and
late passage C6 glioma cells.
Int J Dev Neurosci 14(4), 409-417 (1996) -
Alterations in the growth and protein content of human neuroblastoma cells in vitro
induced by thyroid hormones, stress and ageing.
J Reprod Fertil Suppl 46, 21-33 (1993) -
The aging process.
Ann Intern Med 113(6), 455-466 (1990) -
Histology and survival in age-delayed low-tryptophan-fed rats.
Mech Ageing Dev 43(1), 79-98 (1988) -
Developmental changes in hypothalamic melatonin levels of male rats.
Int J Dev Neurosci 5(4), 313-318 (1987) -
Low tryptophan diets delay reproductive aging.
Mech Ageing Dev 23(3-4), 245-252 (1983) -
Neuroendocrine pacemaker for growth, development and ageing.
Age Ageing 11(2), 73-88 (1982) -
Biological perspectives on aging.
Am Sci 66(5), 605-613 (1978) (no abstract available)
George M. Martin
Professor, Pathology, Adjunct Prof, Genetics
Pathology, Genetics
K-543 Health Sciences Bldg
University of Washington
Washington
USA
Selected Publications:
Medline. At the National Institutes of Health.
- The genetics of aging.
Martin GM
Hosp Pract (Off Ed) 1997 Feb 15 32:2 47-50, 55-6, 59-61 passim
- Somatic mutagenesis and antimutagenesis in aging research.
Martin GM
Mutat Res 1996 Feb 19 350:1 35-41
- Positional cloning of the Werner's syndrome gene.
Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD
Science 1996 Apr 12 272:5259 258-62
- Genetic modulation of telomeric terminal restriction-fragment length: relevance for clonal aging and late-life disease [editorial;
comment]
Martin GM
Am J Hum Genet 1994 Nov 55:5 866-9
- Constitutional genetic markers of aging.
Martin GM
Exp Gerontol 1988 23:4-5 257-70
- Model systems for the genetic analysis of mechanisms of aging.
Martin GM, Turker MS
J Gerontol 1988 Mar 43:2 B33-9
- Life table analysis and pathologic observations in male mice of a long-lived
hybrid strain (Af X C57BL/6)F1.
Wolf NS, Giddens WE, Martin GM
J Gerontol 1988 May 43:3 B71-8
- Workshop on aging and genetics.
Martin GM, Kirkwood T, Fry M, Goldstein S, Brown WT, Salk D
Prog Clin Biol Res 1982 103 Pt A: 339-42
- Syndromes of accelerated aging. Martin GM Natl Cancer Inst Monogr 1982 60: 241-7
Caleb E. Finch
Molecular Neurogerontology
University of Southern California
Los Angeles
California
USA
ARCO/William F. Kieschnick Professor in the Neurobiology of Aging, (Gerontology). Ph.D., 1969 Rockefeller University. Postdoctoral, Rockefeller University
My lab focuses on genomic mechanisms in postnatal development and aging in mammals with particular emphasis on the brain and neural-endocrine interactions. We have recently learned how to obtain clonable mRNA from the human brain postmortem, and are characterizing the changes in mRNA populations during Alzheimer's disease. The responses of genes to steroids in the brain are also being studied to unravel the mechanisms by which estrogens and corticosteroids influence brain aging processes. Ultimately we hope to isolate a set of genes that have crucial roles in brain aging, development, and evolution.
Selected Publications:
Medline. At the National Institutes of Health.
- Johnson, S.A., Morgan, D.G., and Finch, C.E. (1986)
Extensive postmortem stability of RNA from rat and human brain.
J. Neurosci. Res. 16:267-280.
- Pasinetti, G.M., Lerner, S.P., Johnson, S.A., Morgan, D.G., Telford, N.A. and Finch, C.E. (1989)
Chronic lesions differentially decrease tyrosine hydroxylase mRNA in dopaminergic
neurons and the substantia nigra. Molec. Brain Res. 5:203-209.
- Johnson, S.A., McNeill, T., Cordell, B., and Finch, C.E. (1990)
Relation of neuronal App-751/App-695 mRNA ratio and neuritic plaque density in
Alzheimer's disease. Science 248:854-857.
- May, P,C., Lampert-Etchesll, M., Johnson, S.A., Masters, J.N., and Finch, C.E. (1990) Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat. Neuron, 5:831-839.
Peter J. Hornsby
Huffington Center on Aging
Baylor Collage of Medicine,
Houston,
Texas,
U.S.A.
My research concerns mechanisms of cellular aging and differentiation. We use the cells of the adrenal cortex, which secrete glucocorticoid, mineralocorticoid, and androgen hormones, as our model cell type. Our particular interest is in human cell aging. Because this is difficult to study in vivo, we use two experimental methods for studying the aging process of human adrenocortical cells. One is the well established method of growing the cells in culture. We examine the properties of the cells both as a function of donor age and as a function of the number of times they have divided in culture (how close they are to senescence). More recently, we have developed the technology of cell transplantation in immunodeficient (scid - severe combined immunodeficiency) mice. In vivo, human or bovine adrenocortical cells regenerate into a functional tissue structure, which actually replaces the animals' own adrenal gland function. These animals, therefore, form a model not only for the investigation of the properties of human adrenal cells in a real tissue structure in vivo, but also provide a way in which the physiological regulation of human adrenocortical tissue can be studied in mice.
Because of the possibility that adrenal cells might more readily form a tissue structure in mice than other cell types, we are also interested in the potential use of human or bovine adrenal cells as a vehicle for delivery of therapeutic products, which might eventually be applicable to human subjects. For this purpose, we have transfected clonal adrenal cells with test genes to establish that the cells are capable of expressing such genes in the tissue formed from the transplanted cells. The figure illustrates (left side) transplanted clonal cells in mice. (a) shows the cells immediately after introduction into the small (3-mm) cylinder in which they are transplanted. (b - d) shows the vascularized tissue formed from the cells 30 to 50 days later. (Right side) histology of tissue formed from transplanted clonal adrenal cells viewed by DNA-binding dye fluorescence. Mouse cells fluoresce with a different intranuclear pattern from that of human or bovine cells.
Selected Publications:
Medline. At the National Institutes of Health.
- Casson, P.R.; Hornsby, P.J.; Buster, J.E. (1996) Adrenal androgens, insulin resistance, and cardiovascular disease. Sem. Reproductive Endocrinol. 14, 29-34.
- Didenko, V.V.; Hornsby, P.J. (1996) Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis. J. Cell Biol. 135, 1369-1376.
- Didenko, V.V.; Wang, X.; Yang, L.; Hornsby, P.J. (1996) Expression of p21 WAF1/CIP1/SDI1 and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury. J. Clin. Invest. 97, 1723-1731.
- Didenko, V.V.; Hornsby, P.J. (1996) A quantitative luminescence assay for nonradioactive nucleic acid probes. J. Histochem. Cytochem. 44, 657-660.
- Endoh, A.; Kristiansen, S.B.; Casson, P.R.; Buster, J.E.; Hornsby, P.J. (1996) The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex, resulting from its low expression of 3beta-hydroxysteroid dehydrogenase. J. Clin. Endocrinol. Metab. 81, 3558-3565.
- Hornsby, P.J. (1996) Genes, hormones, and aging. Advances in Cell Aging and Gerontology, Vol. 1: Some Aspects of the Aging Process pp. 31-61 Timiras, P.S.; Bittar, E.E., eds. JAI Press Greenwich, CT.
- Sadri, R; Hornsby, P.J. (1996) Rapid analysis of DNA methylation using new restriction enzyme sites created by bisulfite modification. Nucleic Acids Res. 24, 5058-5059.
Michael R. Rose
Professor
Evolutionary Biology of Aging; Evolutionary Genetics
University of California, Irvine
Irvine,
California,
U.S.A.
Why do organisms that have undergone an elaborate process of growth and differentiation to achieve reproductive maturity then proceed to deteriorate, some slowly but some rapidly, over the rest of their lives? This phenomenon of aging is one of the great paradoxes of life, one that has been resolved only in the last ten years. Then again, following Aristotle's comments more than two millennia ago, is this aging related to the health of the young organism, or are youthful function and senescence independent of each other? Put another way, how is fitness connected to aging in the overall determination of life-history?
These are questions that can be answered both theoretically and experimentally. My major scientific focus over the last fifteen years has been experimental tests of evolutionary theories for the evolution of aging, fitness, life-histories, etc., on Drosophila melanogaster , although I collaborate with other investigators using different species. We have experimentally tested the general theory that aging evolves because of a decline in the force of selection with adult age. Another major theme in our work has been the degree to which the population genetics of life-history and deleterious effects at other ages - that is, "trade-offs." We have also been investigating the physiological basis of genetic variation in life-histories.
Among our most important findings are that the biology of aging can be well-explained by the evolutionary theory of aging. In addition, the application of that evolutionary theory can help to unravel the physiological mechanisms of aging. To be more concrete, in our Drosophila system, one of the major limiting factors for later survival and reproduction is the storage of calories in the form of lipid or glycogen. We have managed to double lifespan in fly populations by the use of selection. We have also found that virginity and dietary restriction can be used to postpone aging. We have had some success with the population genetics of postponed aging: out of some 100 or more loci that may be involved, we are on the trail of about ten genes. We are trying to identify these genes so that we can analyze their effects more precisely.
I have also taken up theoretical problems from time to time. Prominent among these are the evolution of genetic systems, especially mechanisms of speciation, the origin of sex, and the maintenance of sex in the face of invading parthenogens. I have also worked on evolutionary game theory, particularly applications to hominid evolution and to the behavior of pathological humans. My inclinations as a theoretician are to start from a novel biological hypothesis, rather than a specific mathematical tool, using models of the greatest possible simplicity.
Selected Publications:
Medline. At the National Institutes of Health.
- Rose, M., and B. Charlesworth. 1980. A test of evolutionary theories
of senescence. Nature 287:141-142.
- Rose, M.R. 1983. The contagion mechanism for the origin of sex. Journal
of Theoretical Biology 101:137-146.
- Rose, M.R. 1987. Quantitative Ecological Theory, An Introduction to Basic
Models. The Johns Hopkins
University Press, New York.
- Rose, M.R. 1989. Genetics of increased lifespan in Drosophila . Bioessays
11:132-135.
- Rose, M.R. 1991. Evolutionary Biology of Aging. Oxford University Press,
New York.
- M.R. Rose and G.V. Lauder, Editors. 1996. Adaptation. Academic Press, New
York.
- M.R. Rose and C.E. Finch, Editors. 1994. Genetics and Evolution of Aging.
Kluwer Academic Publishers, Dordrecht, the Netherlands.
- M.R. Rose. 1991. Evolutionary Biology of Aging. Oxford
University Press, New York.
- A.K. Chippindale, A.M. Leroi, H. Saing, D.J. Borash & M.R. Rose. In press.
Phenotypic
plasticity and selection in Drosophila life-history evolution.
2. Diet, mates and the
cost of reproduction. Journal of Evolutionary Biology.
- M.R. Rose. In press. Evolution and comparative longevity. In Encyclopedia
of Gerontology
- J. Shiotsugu, A.M. Leroi, H. Yashiro, M.R. Rose & L.D. Mueller. 1997. The
symmetry
of correlated selection responses in adaptive evolution: An
experimental study
using Drosophila. Evolution, In press.
- M.R. Rose & M.A. Archer. 1996. Genetic analysis of mechanisms of aging.
Current Opinion
in Genetics and Development 6:366-70.
- J.E. Fleming & M.R. Rose. 1996. Genetics of aging in Drosophila. Pp. 74-93
in Handbook of the Biology of Aging. E.L. Schneider & J.W. Rowe, Eds.
Academic Press, New York.
- M. Djawdan, T. Sugiyama, L. Schlaeger, T.J. Bradley, & M.R. Rose. 1996.
Metabolic aspects of the trade-off between fecundity and longevity in
Drosophila melanogaster. Physiological Zoology 69:1175-1195.
- T.J. Nusbaum, L.D. Mueller, & M.R. Rose. 1996. Evolutionary patterns
among measures
of aging. Experimental Gerontology 31:507-516.
- A.K. Chippindale, T.J.F. Chu & M.R. Rose. 1996. Complex trade- offs and
the evolution
of starvation resistance in Drosophila melanogaster. Evolution
50:753-66.
- L.D. Mueller, T.J. Nusbaum & M.R. Rose. 1995. The Gompertz equation as a
predictive
tool in demography. Experimental Gerontology 30:553-569.
- C.E. Finch & M.R. Rose. 1995. Hormones and the physiological architecture
of life-history
evolution. Quarterly Review of Biology 70: 1-52.
- A.K. Chippindale, D.T. Hoang, P.M. Service & M.R. Rose. 1994. The
evolution of development in Drosophila melanogaster selected
for postponed senescence. Evolution
48: 1880-1899.
- A.M. Leroi, A.K. Chippindale & M.R. Rose. 1994. Long-term laboratory
evolution of a
genetic trade-off in Drosophila melanogaster. I. The role of
genotype x environment
interaction. Evolution 48: 1244-1257.
- A.M. Leroi, W.R. Chen & M.R. Rose. 1994. Long-term laboratory evolution
of a
genetic trade-off in Drosophila melanogaster. II. Stability
of genetic correlations.
Evolution 48: 1258-1268.
- A.M. Leroi, S.B. Kim & M.R. Rose. 1994. The evolution of phenotypic
life-history trade-
offs: an experimental study using Drosophila melanogaster.
American Naturalist 144:661-676.
- M.R. Rose & T.J. Nusbaum. 1994. Prospects for postponing human aging.
FASEB Journal 8: 925-928.
- T.J. Nusbaum & M.R. Rose. 1994. Aging in Drosophila. Comparative
Biochemistry and Physiology 109A: 33-38.
- A.M. Leroi, M.R. Rose & G.V. Lauder. 1994. What does the comparative
method
reveal about adaptation? American Naturalist 143: 381-402.
- J.E. Fleming, G.S. Spicer, R.C. Garrison & M.R. Rose. 1993. Two
dimensional protein
electrophoretic analysis of postponed aging in Drosophila.
Genetica 91: 183-198.
- R.H. Tyler, H. Brar, M. Singh, A. Latorre, J.L. Graves, L.D. Mueller, M.R.
Rose & F.J. Ayala.1993. The effect of superoxide dismutase alleles on
aging in Drosophila. Genetica
91: 143-149.
- L.D. Mueller, J.L. Graves, & M.R. Rose. 1993. Interactions
between density-dependent and age-specific selection in Drosophila
melanogaster. Functional Ecology 7:469-479.
- G.V. Lauder, A.M. Leroi & M.R. Rose. 1993. Adaptations and history.
Trends in
Ecology and Evolution 8:294-297.
- A.K. Chippindale, A.M. Leroi, S.B. Kim, & M.R. Rose. 1993.
Phenotypic plasticity and selection in Drosophila life-history evolution.
I. Nutrition and the cost of reproduction. J. Evol. Biology 6:171-193.
- M.R. Rose, T.J. Nusbaum, & James E. Fleming. 1992. Drosophila
with postponed aging as a model for aging research. Lab. Animal Sci.
42:114-118.
- M.R. Rose, L.N. Vu, S.U. Park, & J.L. Graves. 1992. Selection
for stress resistance increases longevity in Drosophila melanogaster.
Exp. Gerontol. 27: 241-250.
- J.L. Graves, E.C. Toolson, C. Jeong, L.N. Vu, & M.R. Rose. 1992.
Desiccation, flight, glycogen, and postponed senescence in Drosophila
melanogaster. Physiol. Zool. 65:268-286.
- R.E. Lenski, M.R. Rose, S.E. Simpson, & S.C. Tadler. 1991.
Long-term experimental evolution in Escherichia coli. I. Adaptation and
divergence during 2000 generations. Am. Nat. 138: 1315-1341.
- M.R. Rose & G.V. Lauder. 1996. Post-spandrel adaptationism. In
Adaptation. M.R. Rose & G.V. Lauder, Eds. Academic Press, New York.
- M.R. Rose, A.K. Chippindale & T.J. Nusbaum. 1996. Laboratory
evolution: the experimental wonderland and the Cheshire Cat Syndrome. In
Adaptation. M.R. Rose & G.V. Lauder, Eds. Academic Press, New York.
- C. Moore & M.R. Rose. 1995. Adaptive and nonadaptive explanations
of sociopathy.Brain & Behavioral Sciences 18:566-567.
- M.R. Rose & C.E. Finch. 1993. The Janiform genetics of aging.
Genetica 91: 3-10.
- M.R. Rose & C. Moore. 1993. A Darwinian function for the
orbital cortex. J. Theor. Biology. 161: 119-129.
.
J.C. Carlson
BSc, MSc, PhD (Massachusetts)
University of Waterloo,
Waterloo,
Ontario,
Canada
Email: jcarlson@sciborg.uwaterloo.ca
Research Interests
Physiology of the mammalian reproductive system; mechanisms of corpus luteum regression. Studies on the process of aging.
Selected Publications:
Medline. At the National Institutes of Health.
- Riley, J.C.M. and Carlson, J.C. Aluminum - Alzheimer's smoking gun? Canadian Journal on Aging 14: 613-616, 1995.
- Milvae, R.A., Hinckley, S.T. and Carlson, J.C. Luteotropic and luteolytic mechanisms in the bovine corpus luteum. Theriogeneology, May 1996.
- Sawada, M. and Carlson, J.C. Intracellular regulation of progesterone secretion by the superoxide radical in the rat CL. Endocrinology 137: 1580-1584, 1996.
- Rollo, C.D., Carlson, J.C. and Sawada, M. Accelerated aging of giant transgenic mice is associated with elevated free radical processes. Can. J. Zool. 74: 606-620, 1996.
- Carlson, J.C. and Sawada, M. The free radical theory of aging and a look at changes in the hypothalamus. Canadian Journal on Aging 15: 44-53, 1996.
- Carlson, J.C. and Sawada, M. Generation of free radicals and messenger function. Canadian J. Applied Physiology 20: 280-288, 1995.
- Carlson, J.C., Sawada, M., Boone, D.R. and Stauffer, J.M. Stimulation of progesterone secretion in dispersed cells of rat corpora lutea by antioxidants. Steroids, 66: 272-276, 1995.
- Sawada, M. and Carlson, J.C. Studies on the mechanism controlling generation of superoxide radical in luteinized rat ovaries during regression. Endocrinology 135: 1645-1650, 1994.
- Shi, L., Sawada, M., Sester, U. and Carlson, J.C. Alterations in free radical acitivity in aging Drosophila. Experimental Gerontology 29: 575-584, 1994.
- Sawada, M., Sester, U., Wu, X.M. and Carlson, J.C. Protein changes in the rat corpus luteum during luteolysis. Serono Symposium, Molecular Basis of Reproductive Endocrinology, Vancouver, BC, July 1991. P.C.K. Leung, A.J.W. Hseuh and H.G. Friesen, eds. Springer Verlag Publisher, N.Y. Chap. 22, pp. 257-263, 1993.
- Wu, X., Yao, K. and Carlson, J.C. Plasma membrane changes in the rat corpus luteum induced by oxygen radical generation. Endocrinology 133: 491-495, 1993.
- Sawada, M., Sester, U. and Carlson, J.C. Changes in superoxide radical formation, lipid peroxidation, membrane fluidity and proteolytic activity in aging and spawning salmon. Mechanisms of Aging and Development 69: 137-148, 1993.
- Yao, K., Wu, X., Thompson, J.E. and Carlson, J.C. Isolation and characterization of deteriosomes from rat liver. J. Cell. Biochem. 51: 488-494, 1993.
- Carlson, J.C., Wu, X.M. and Sawada, M. Oxygen radicals and the control of ovarian corpus luteum function. Free Radical Biology and Medicine, 14: 79-84, 1993.
- Wu, X.M., Sawada, M. and Carlson, J.C. Stimulation of pholpholipase A2 by xanthine oxidase in the rat corpus luteum. Biol. Reprod. 47: 1053-1058, 1992.
- Carlson, J.C. and Forbes, W.F. The free radical theory of aging. A critique and unresolved questions. Canadian Journal on Aging. 11, 1992.
- Sawada, M., Sester, U. and Carlson, J.C. 1992. Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart and liver during the lifetime of the rat. J. Cell Biochemistry. 48: 1-9.
- Carlson, J.C. 1991. Book Review: Annual Review of Gerontology and Geriatrics, Vol. 10, V.J. Cristofolo ed., Canadian Journal on Aging. 10: 376-378, 1991.
- Sawada, M. and Carlson, J.C. 1991. Rapid plasma membrane changes in superoxide radical formation, fluidity and phospholipase A2 activity in the corpus luteum of the rat during induction of luteolysis. Endocrinology. 128: 2992-2998.
- Sestini, E.A., Carlson, J.C. and Allsopp, R. 1991. The effects of ambient temperature on life span, lipid peroxidation, superoxide dismutase and phospholipase A2 activity in Drosophila melanogaster. Exp. Geront. 26: 385-396.
- Wu, X. and Carlson, J.C. 1990. Alterations in phospholipase A2 activity during luteal regression in pseudopregnant and pregnant rats. Endocrinology 127:2464-2468.
- Sawada, M. and Carlson, J.C. 1990. Biochemical changes associated with the mechanism controlling superoxide radical formation in the aging rotifer. J. Cell. Biochem. 44: 153-165.
- Carlson, J.C., Hahn, P., So, K. and Chan, A. 1990. Studies on prostaglandin and luteolysis in the pseudopregnant rabbit. Endocr. Res. 16: 193-204.
- Sawada, M., Carlson, J.C. and Enesco, H.E. 1990. The effects of U.V. radiation and antioxidants on life-span and lipid peroxidation in the rotifer Asplanchna Brightwelli. Archives Gerontology Geriatrics, 10:27-36.
.
Calvin B. Harley
Geron Corporation
200 Constitution Dr.
Menlo Park,
California,
U.S.A.
Dr. Harley was an Associate Professor from 1989 until going to Geron Corporation, and from 1982 to 1989, he was Assistant Professor of Biochemistry at McMaster University. He also was the Chair of the Canadian Association on Gerontology, Division of Biological Sciences from October 1989 to October 1991 and Chairman Elect from 1987 to 1989. Dr. Harley recieved a B.S. from the University of Waterloo and a Ph.D. from McMaster University. He performed postdoctoral work at the University of California at San Francisco and at the University of Sussex .
Selected Publications:
Medline. At the National Institutes of Health.
- Replicative senescence and cell immortality: the role of telomeres and telomerase.
Chiu CP, Harley CB
Proc Soc Exp Biol Med 1997 Feb 214:2 99-106
- Telomere length and replicative aging in human vascular tissues.
Chang E, Harley CB
Proc Natl Acad Sci U S A 1995 Nov 21 92:24 11190-4
- Telomere shortening is associated with cell division in vitro and in vivo.
Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, Harley CB
Exp Cell Res 1995 Sep 220:1 194-200
- Telomeres and telomerase in aging and cancer.
Harley CB, Villeponteau B
Curr Opin Genet Dev 1995 Apr 5:2 249-55
- Telomere length and replicative aging in human vascular tissues.
Chang E, Harley CB
Proc Natl Acad Sci U S A 1995 Nov 21 92:24 11190-4
- Evidence for a critical telomere length in senescent human fibroblasts.
Allsopp RC, Harley CB
Exp Cell Res 1995 Jul 219:1 130-6
- Telomeres and telomerase in aging and cancer.
Harley CB, Villeponteau B
Curr Opin Genet Dev 1995 Apr 5:2 249-55
- Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.
Vaziri H, Schächter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Harley CB
Am J Hum Genet 1993 Apr 52:4 661-7
- The telomere hypothesis of cellular aging.
Harley CB, Vaziri H, Counter CM, Allsopp RC
Exp Gerontol 1992 Jul-Aug 27:4 375-82
- Telomere length predicts replicative capacity of human fibroblasts.
Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB
Proc Natl Acad Sci U S A 1992 Nov 1 89:21 10114-8
- Telomere end-replication problem and cell aging.
Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB
J Mol Biol 1992 Jun 20 225:4 951-60
- Some aspects of cellular aging.
Goldstein S, Harley CB, Moerman EJ
J Chronic Dis 1983 36:1 103-16
- Protein synthetic errors do not increase during aging of cultured human fibroblasts.
Harley CB, Pollard JW, Chamberlain JW, Stanners CP, Goldstein S
Proc Natl Acad Sci U S A 1980 Apr 77:4 1885-9
- Is cellular aging a stochastic process?
Shmookler Reis RJ, Goldstein S, Harley CB
Mech Ageing Dev 1980 13:4 393-5
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