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MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study.
- Tapiola T, Pennanen C, Tapiola M, Tervo S, Kivipelto M, Hanninen T, Pihlajamaki M, Laakso MP, Hallikainen M, Hamalainen A, Vanhanen M, Helkala EL, Vanninen R, Nissinen A, Rossi R, Frisoni GB, Soininen H
Neurobiol Aging. 2006 Nov 9;.
The concept of mild
cognitive
impairment (MCI) has been proposed
to represent a transitional stage between normal aging
and dementia.
We studied the predictive value of the MRI-derived volumes of medial
temporal lobe
(MTL) structures, white matter
lesions (WML), neuropsychological tests,
and Apolipoprotein
E
(APOE) genotype
on conversion of MCI to dementia
and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients
had progressed to dementia
(9 to Alzheimer's disease
(AD)). In Cox regression analysis
the baseline
volumes of the right hippocampus, the right entorhinal cortex
and CDR sum of boxes predicted the progression of MCI to dementia
during the follow-up. In a bivariate analysis,
only the baseline
volumes of entorhinal cortex
predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline,
WML load, or APOE genotype
were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.
This abstract at PubMed.