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Oxidative imbalance in the aging inner ear.
- Jiang H, Talaska AE, Schacht J, Sha SH
Neurobiol Aging. 2006 Aug 18;.
The mammalian inner ear loses its sensory
cells with advancing age, accompanied by a functional decrease in balance and hearing.
This study investigates oxidant
stress in the cochlea
of aging
male CBA/J mice. Glutathione-conjugated proteins,
markers of H(2)O(2)-mediated oxidation,
began to increase at 12 months of age; 4-hydroxynonenal and 3-nitrotyrosine, products of hydroxyl radical
and peroxynitrite action, respectively, were elevated by 18 months. Immunoreactivity to these markers was stronger in the supporting cells (Deiters and pillar
cells) than the sensory
cells and appeared later (23 months) in spiral ganglion
cells and in the stria vascularis
and spiral ligament. Conversely, antioxidant
proteins
(AIF) and enzymes (SOD2) decreased by 18 months in the organ of Corti
(including the sensory
cells) and spiral ganglion
cells but not in the stria vascularis.
These results suggest the presence of different reactive oxygen species
and differential
time courses of oxidative changes in individual tissues of the aging
cochlea.
An imbalance of redox status
may be a component
of age-related hearing
loss.
This abstract at PubMed.
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