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Pharmacokinetics of verapamil in New Zealand white rabbits during ontogeny.
- Solans C, Bregante MA, Aramayona JJ, Fraile LJ, Garcia MA
Biol Neonate. 2000 Nov;78(4):321-6.
The pharmacokinetics
of verapamil
during ontogeny
in rabbits and in vitro
verapamil
demethylase activity have been investigated in the liver
and whole blood.
In vivo
experiments revealed that the slope of the postdistributive phase as well as the area under the curve
and clearance
showed significant differences when newborn and adult rabbits were compared. Other pharmacokinetic parameters, such as volume of distribution and plasma protein
binding
did not show any statistical differences. Liver
microsomal
preparation
samples from 1-, 8- and 16-day-old rabbits displayed approximately 20% of the activity observed in adults. A significant verapamil
demethylase activity in the whole blood
of rabbits was also noted. The in vivo
results show that newborn rabbits have a capacity to eliminate verapamil
that is similar or even higher than that of adults. These findings could not be explained with regard to the in vitro
liver
metabolism
of verapamil,
although they could with respect to blood metabolism.
This abstract at PubMed.