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Clonal organization in the postnatal mouse central nervous system is prefigured in the embryonic neuroepithelium.
- Mathis L, Nicolas JF
Dev Dyn. 2000 Oct;219(2):277-81.
We have used the LaacZ clonal method of cell labeling of neuronal
ancestors and report that the spatial organization
of neuronal
cells in the post-natal CNS
shares striking similarities to that in the embryonic neuroepithelium,
from the spinal cord
to the diencephalon.
The maintenance
of the organization
occurs despite massive cell divisions and morphogenetic movements. We deduce that the cellular and architectural organization
in the mouse CNS
results from a succession of patterns of oriented cell dispersion,
a general arrest
of cell dispersion
in the neuroepithelium,
and then well-documented radial
neuronal
migration. The arrest
of cell dispersion
in the neuroepithelium
is consistent with the possibility that an important part of the cellular and architectural organization
of the mature CNS
requires conservation
of spatial relationship between cells and supports the hypothesis of a transition from global and sparse
to local and dense cell interactions occurring early within the neuroepithelium.
This abstract at PubMed.