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Expression of the genes of arginine-synthesizing enzymes in the rat kidney during development.
- Goutal I, Fairand A, Husson A
Biol Neonate. 1999 Oct;76(4):253-60.
The expression of two genes,
coding for argininosuccinate synthetase
(ASS) and argininosuccinate lyase
(ASL), enzymes which synthesize arginine,
was studied by Northern analysis
in various tissues of fetal
rats. The highest expression of both genes
was seen in the small intestine,
liver
and kidney of the fetus.
The developmental expression was observed in the kidney where both mRNA
levels remained low during the fetal
period and they increased concomitantly in both kidney and liver
throughout the perinatal
life, suggesting that the aptitude
to synthesize arginine
appeared and developed within the same period in both organs. This developmental activation
of the ASS and ASL genes
expression corresponded, at least in part, to a transcriptional mechanism
in both tissues, as measured by run-on assay.
Bilateral
adrenalectomy
showed that glucocorticoids
did not appear to control
the developmental expression of both genes
in the kidney, in contrast to the situation observed in the liver.
This abstract at PubMed.